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March 26, 2026Journal of Antimicrobial Chemotherapy0 citationsOpen Access

Pharmacological evaluation of an ex vivo cervicovaginal HIV prevention model

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LCLindsey CollinsUniversity of MinnesotaALAn Van LeDuy Tan UniversityMNMelanie R. NicolUniversity of Minnesota

Key Points

  • The aim is to evaluate differences in drug metabolism and antiviral responses in cervical tissues to improve HIV prevention strategies.
  • Utilized ecto- and endocervical tissue explants in an ex vivo model
  • Assessed DMET expression and ARV metabolism
  • Evaluated viral infectivity and dose-dependent drug inhibition
  • Identified differences in DMET expression between ecto- and endocervical tissues
  • Observed consistent viral infectivity in ectocervical explants
  • Demonstrated dose-dependent inhibition of viral activity
  • Established correlations between DMET expression and IL-6 levels

Abstract

We identified differences in DMET expression and ARV metabolism between ecto- and endocervical tissues, as well as correlations between DMET and IL-6. Ectocervical explants demonstrated consistent viral infectivity and dose-dependent inhibition. The model is useful in determining tenofovir diphosphate targets.

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Cite This Study

Collins et al. (2026) studied this question.

synapsesocial.com/papers/69c4ccc9fdc3bde448918635https://doi.org/10.1093/jac/dkag103
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