Development of herbicide-resistant peanut via prime editing and optimization of editing efficiency

Lulu Xue; Pengyu QU; Huanhuan Zhao; Han Liu; X. H. Li; Xiuli Wang; Bingyan Huang; Suoyi Han; Xiaodong Dai; Wenzhao Dong; Lei Shi; Xinyou Zhang

doi:10.1093/plphys/kiag116

March 1, 2026PLANT PHYSIOLOGYOpen Access

Development of herbicide-resistant peanut via prime editing and optimization of editing efficiency

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Key Points

This research aims to enhance the efficiency of prime editing to confer herbicide resistance in peanuts.
Utilized prime editing technique to target acetolactate synthase gene.
Introduced W574L mutation to assess its impact on herbicide resistance.
Analyzed editing efficiency and mutation outcomes.
Confirmed that the W574L mutation provides broad-spectrum herbicide resistance.
Editing efficiency observed was suboptimal and highlighted for further improvement.

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Implication

Prime editing enables herbicide resistance in peanuts, indicating potential for improved crop resilience.

Abstract

Prime editing of acetolactate synthase to introduce the W574L mutation confers broad-spectrum herbicide resistance in peanut, though efficiency remains suboptimal and requires further refinement.

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Cite This Study

Xue et al. (2026) studied this question.

synapsesocial.com/papers/69c4cd49fdc3bde448919789 https://doi.org/10.1093/plphys/kiag116

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Development of herbicide-resistant peanut via prime editing and optimization of editing efficiency

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Development of herbicide-resistant peanut via prime editing and optimization of editing efficiency

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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