Fusobacterium nucleatum: A time to bridge mechanistic insights of pathogenesis into clinical applications in managing oral squamous cell carcinoma

Q: What does this research mean for the field?

Fusobacterium nucleatum drives the progression of oral squamous cell carcinoma and serves as a promising biomarker and therapeutic target, warranting the clinical translation of current mechanistic insights. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Zhiwei Guan; Qiang Feng

doi:10.1016/j.tdr.2025.100049

March 25, 2026Translational dental research.Open Access

Fusobacterium nucleatum: A time to bridge mechanistic insights of pathogenesis into clinical applications in managing oral squamous cell carcinoma

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Key Points

To explore the role of fusobacterium nucleatum in the progression of oral squamous cell carcinoma and its clinical applications.
Investigate the mechanisms by which Fn contributes to OSCC progression.
Evaluate Fn as a biomarker for OSCC diagnosis and prognosis.
Assess potential therapeutic strategies targeting Fn in OSCC.
Fn drives OSCC progression through multiple mechanisms.
Fn shows potential as a reliable biomarker for diagnosing and predicting OSCC outcomes.
Highlighting Fn as a promising target for therapeutic intervention in OSCC management.

Implication

Uncovers fusobacterium nucleatum's role in oral squamous cell carcinoma, suggesting its potential for diagnosis and treatment.

Abstract

• Fusobacterium nucleatum ( Fn ) drives the progression of oral squamous cell carcinoma (OSCC) through multiple mechanisms. • Fn can be used as a biomarker for the diagnosis/prognosis of OSCC. • Fn is a promising therapeutic target for OSCC. • Equal emphasis should be placed on mechanistic insights into pathogenesis and clinical translations in Fn -associated OSCC.

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Cite This Study

Guan et al. (2026) studied this question.

synapsesocial.com/papers/69c4cd5afdc3bde448919805 https://doi.org/10.1016/j.tdr.2025.100049

View Full Paper

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Fusobacterium nucleatum: A time to bridge mechanistic insights of pathogenesis into clinical applications in managing oral squamous cell carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

Fusobacterium nucleatum: A time to bridge mechanistic insights of pathogenesis into clinical applications in managing oral squamous cell carcinoma

Key Points

Implication

Abstract

Discussion

Cite This Study

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