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Anti-signal recognition particle antibody-positive immune-mediated necrotizing myopathy with inclusion body myositis-like features in a patient with human immunodeficiency virus and syphilis infection

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To describe a patient with both immune-mediated necrotizing myopathy and inclusion body myositis features linked to HIV infection.
Detailed clinical case study of a 40-year-old HIV-positive man
Assessment of muscle strength, dysphagia, and creatine kinase levels
Serological testing for antibodies
Muscle biopsy for pathological examination
Evaluation of treatment response to various therapies
Patient exhibited significant muscle weakness, dysphagia, and elevated creatine kinase levels.
Strong positivity for anti-signal recognition particle antibodies was found.
Muscle biopsy indicated pathological features of both myopathies.
The patient responded well to intravenous immunoglobulin therapy after insufficient response to other treatments.

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Case report reveals coexisting immune-mediated necrotizing myopathy and inclusion body myositis in HIV, suggesting new treatment options.

Nagao et al. (2026) studied this question.

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