Retrospective cohort study evaluates mortality and fluid balance in critically ill patients with Pneumocystis, suggesting early enteral therapy may be beneficial.
Key Points
This study investigates the effects of early versus late enteral conversion of TMP-SMX on mortality and fluid balance in ICU patients with PCP.
Retrospective cohort design focusing on adult ICU patients with PCP treated with TMP-SMX.
Patients stratified into early conversion (≤48 hours of initiation) and late conversion groups.
Admired the effect of conversion timing on 90-day mortality and mean daily fluid balance.
Multivariable Cox proportional hazards regression analysis was utilized.
Of 183 patients, 108 had early enteral conversion and 75 had late conversion.
90-day mortality was lower in the early conversion group (50.9%) compared to the late group (61.3%).
After adjusting for confounders, early conversion did not significantly impact mortality (HR 0.74, 95% CI 0.50 - 1.11).
Early conversion group trended towards a better mean daily fluid balance (-0.443 L vs -0.127 L, p=0.05).