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March 26, 2026Journal of Neurology0 citationsOpen Access

Treatment-related modulation of visuo-vestibular integration in post-earthquake dizziness syndrome: a longitudinal virtual reality–based study

HKHanifi KorkmazTurgut Özal Tıp MerkeziIKIşıl Çakmak KaraerKOKübra Orman

Key Points

  • To assess the long-term impacts of VR and CBT therapies on visuo-vestibular processing and symptoms in adults after earthquakes.
  • Conducted a four-arm longitudinal study with 48 adults exposed to earthquakes.
  • Evaluated participants at baseline, after an 8-week intervention, and at a 3-month follow-up.
  • Used a virtual reality system for objective testing of visuo-vestibular outcomes including SVV, DSVV, RFT, and VMS.
  • Assessed subjective outcomes through DHI and PCL-5 surveys.
  • Participants showed improvement in dizziness-related disability and trauma symptoms over time.
  • SVV and DSVV measures remained stable, while RFT improved in treatment groups, indicating reduced visual frame dependence.
  • The VR + CBT group displayed the most consistent enhancements in VMS under challenging visual conditions.

Abstract

Abstract Background Post-earthquake dizziness syndrome (PEDS) is increasingly recognized as a condition marked by persistent dizziness and imbalance after major earthquakes, often without clear peripheral vestibular pathology. Despite proposed roles of visuo-vestibular dysfunction and sensory conflict, longitudinal objective evidence remains limited. Objective To examine the longitudinal effects of virtual reality–based vestibular rehabilitation (VR), cognitive behavioral therapy (CBT), and their integration (VR + CBT) on objective visuo-vestibular processing and symptom burden in adults with PEDS. Methods In a four-arm longitudinal study, 48 earthquake-exposed adults with PEDS were evaluated at baseline, post-intervention, and 3-month follow-up following an 8-week intervention. Objective visuo-vestibular outcomes were assessed using an immersive virtual reality–based system, including static and dynamic subjective visual vertical (SVV/DSVV), rod-and-frame test (RFT), and visual motion sensitivity (VMS) tests. Subjective outcomes included dizziness-related handicap (DHI) and post-traumatic stress symptoms (PCL-5). Results Dizziness-related disability and trauma-related symptoms improved over time across groups, indicating clinical modifiability of PEDS. Objective measures demonstrated a domain-specific response profile: SVV and DSVV remained largely stable, whereas RFT showed improvement in active treatment arms, suggesting reduced visual frame dependence. VMS outcomes exhibited differential trajectories, with the integrated VR + CBT group showing the most consistent and durable modulation under visually provocative conditions. Conclusions Recovery in PEDS appears to involve selective modulation of context-dependent visuo-vestibular processing rather than uniform changes across all spatial orientation measures. Integrated VR + CBT yields the most coherent and durable benefits in visually demanding domains, supporting multidisciplinary models that jointly address sensory conflict and cognitive–emotional mechanisms after major earthquakes.

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Cite This Study

Korkmaz et al. (2026) studied this question.

synapsesocial.com/papers/69c4cdb6fdc3bde44891a665https://doi.org/10.1007/s00415-026-13767-4
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