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Investigating water balance in obesity reveals links between blood, tissue levels, and body mass index.
Obesity is a risk factor for hypertension, and it has been considered that volume overload is one of the mechanisms of blood pressure elevation in obesity. On the other hand, recent basic and clinical studies suggest that there is disequilibrium in water balance between the blood and each tissue. However, the effects of obesity on water balance at the tissue level are unclear. In this study, we examined the water balance between the blood and tissue levels in high-fat diet-induced obese mice. We also evaluated the association between Body Mass Index (BMI) and tissue water content in human skin.
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Kitada et al. (2026) studied this question.
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