WCN26-6311 An ultrasmall ruthenium-based nanoparticle to protect acute kidney injury and promote renal repair

Acute kidney injury (AKI) is common, with high morbidity and mortality. However, treatment options are limited. Many studies have shown a strong link between AKI and the development of chronic kidney disease (CKD), with AKI greatly increasing the risks of CKD and end-stage renal disease (ESRD). Recently, nanotechnology-based antioxidative therapy has emerged as a promising approach to alleviating oxidative stress caused by excessive reactive oxygen species (ROS). This study reports an ultrasmall ruthenium-based nanoparticle as a ROS scavenger to mitigate AKI and promote renal repair in C57 mice.