WCN26-3627 Modeling Crescentic Glomerulonephritis in Mice via Bovine NC1 Domain of Type IV Collagen: A Low-Mortality Approach

Crescents are characteristic histopathological findings in ANCA-associated vasculitis (AAV) and anti-GBM antibody-mediated rapidly progressive glomerulonephritis. They consist of cellular and interstitial aggregates filling Bowman’s space, and nephrons with crescent formation lose their ability to filter plasma and produce primary urine. Although crescents are associated with poor prognosis, their formation mechanism remains unclear, and no definitive treatment has been established. Animal models are essential for elucidating disease mechanisms and developing therapies.