Systematic review finds neuroprotective care bundles reduce severe intraventricular haemorrhage in preterm infants, suggesting effective care standardization.
Intraventricular Haemorrhage (IVH) is the most frequently occurring neurological injury witnessed in extremely premature infants. Neuroprotective care bundles (NCBs) have been piloted in NICUs worldwide in a bid to reduce the overall incidence of IVH. This study was conducted utilising PubMed, EBSCO, Cochrane Library, Medline, CINAHL Plus Full Text and a search of the grey literature from January 2024 to April 2025. PRISMA framework was employed, and narrative synthesis was implemented to discuss the findings of this systematic review. Thirteen studies were included involving 9504 infants admitted to NICUs across six different countries. Ten of the included studies suggested the application of NCBs are correlated with a statistically significant reduction in severe IVH in NICU. Conversely, three studies demonstrated no effect on severe IVH incidence post implementation of an NCB. This review highlights the potential effectiveness of the standardisation of care for preterm neonates.
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Mulvihill et al. (2026) studied this question.
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