Front Cover: Development of a C5‐Azidoacetamide‐Modified 4‐Amino‐2,3‐Difluorosialic Acid Activity‐Based Probe for Labeling of Influenza A Neuraminidases (ChemBioChem 6/2026)

Hands “build” a chemical probe by adding distinctive functional groups to a natural neuraminic acid scaffold. The central ball-and-stick model depicts the modified sialic acid core, while the colored add-ons represent engineered handles that convert a native carbohydrate into an activity-based probe. Influenza virions in the background spotlight the target enzyme, neuraminidase, and the probe’s utility for labeling and tracking its activity in complex samples. More details can be found in the Research Article by Tom Wennekes and co-workers (DOI: 10.1002/cbic.70288).