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March 24, 2026Current Drug Targets

Research on the Anti-breast Hyperplasia Mechanism of Liqi Sanjie Granules Based on Network Pharmacological Analysis and ExperimentalVerification

Xionghui Hu Xun Liu Rensong Yan Xianhai Li You Zhou Fei Chen Min Xu Cheng Xiao Yi Wang Zhang Wang Yao Liu Bingguang Zhong Xiaoqi Hu Qing Zhou Tanjun Wei

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Key Points

This research aims to investigate the anti-breast hyperplasia mechanisms of Liqi Sanjie Granules (LSG) using network pharmacology and experimental methods.
Quantified chemical components of LSG via HPLC and LC-MS.
Established a rat model of breast hyperplasia using estradiol benzoate and progesterone.
Monitored changes using histopathological analysis and various detection methods for hormone levels.
Seven components of LSG quantified; key components found include paeoniflorin, glycyrrhizin, and ferulic acid.
Histopathological analysis showed reduced mammary gland hyperplasia in LSG-treated rats.
LSG decreased expression of progesterone receptors and estrogen receptor mRNA in mammary tissues.

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Implication

Research shows Liqi Sanjie Granules affect targets in breast hyperplasia, suggesting a new treatment approach.

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Cite This Study

Hu et al. (2026) studied this question.

synapsesocial.com/papers/69c6209315a0a509bde19110 https://doi.org/10.2174/0113894501441176260118230500

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