Patient-Drug Related Factors Associated with Nonadherence to Chronic Treatment in Patients Attending a Primary Care Setting in South Africa

Background: Medication nonadherence among patients with chronic diseases represents a major challenge in healthcare systems worldwide and is associated with poor clinical outcomes, increased hospitalizations, and higher healthcare costs. Patient-drug related factors such as knowledge of treatment, beliefs about medication, and the experience of side effects may significantly influence adherence behaviour. Methods: A cross-sectional quantitative study was conducted among 80 patients receiving treatment for chronic conditions at a primary healthcare facility in South Africa. Data were collected through face-to-face interviews using a standardized questionnaire that assessed demographic characteristics and patient-drug-related factors potentially associated with medication adherence. Statistical analysis was performed using IBM SPSS Version 30.0.0.0 (172). Descriptive statistics were used to summarize participant characteristics, while inferential analyses, including chi-square tests and Fisher’s exact tests, were applied to determine associations between demographic variables, patient-drug related factors, and medication nonadherence. Results: The majority of participants were female, aged between 41 and 50 years, single, unemployed, and had completed secondary education. Most participants lived in rural areas, and HIV/AIDS was the most commonly reported chronic condition. Significant associations with medication nonadherence were identified for the experience of medication side effects and inadequate knowledge about treatment. These factors demonstrated moderate effect sizes and suggest that both clinical and educational aspects of treatment may influence adherence behaviour. Conclusions: Patient-drug related factors, particularly medication side effects and insufficient knowledge regarding treatment, play a significant role in medication nonadherence among patients with chronic conditions in primary care settings. Interventions aimed at improving patient education, counselling regarding medication side effects, and strengthening patient-provider communication may help improve adherence and treatment outcomes.