Bridging the gap: gradient scaffolds as bioinstructive platforms for peripheral nerve repair

Key Points

• The aim is to explore how gradient scaffolds can improve peripheral nerve repair by affecting cellular behavior.
• Reviewed existing gradient scaffold designs.
• Discussed materials and chemical strategies for scaffolding.
• Analyzed the relationship between scaffold architecture and nerve regeneration outcomes.
• Gradient scaffolds enhance cellular behavior in nerve repair.
• Specific architectures improve nerve regeneration effectiveness.
• Linking fabrication strategies to outcomes can guide future designs.