Rapid Desiccation and On-disc Rehydration of Extracellular Vesicles for Non-cryogenic Preservation

Hyun-Kyung Woo; Sangjin Seo; Advitiya Mahajan; Seoyoung Lee; Seoyoon Bae; Jeremy M. Quintana; Changhyun Kim; Alptekin Aksan; Hakho Lee

doi:10.1039/d6lc00014b

January 1, 2026Lab on a Chip

Rapid Desiccation and On-disc Rehydration of Extracellular Vesicles for Non-cryogenic Preservation

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Key Points

To explore a novel method for the rapid desiccation and rehydration of extracellular vesicles (EVs) for preservation without cryogenics.
Developed a protocol for rapid desiccation of EVs.
Applied on-disc rehydration techniques to restore EV function.
Evaluated effectiveness through biochemical assays and functional tests.
Demonstrated high recovery rates of EVs after rehydration.
Maintained biological function of EVs post-preservation.
Showed reduced storage costs and logistical requirements compared to traditional methods.

Implication

Demonstrates a new method for preserving extracellular vesicles, suggesting improved options for clinical use.

Abstract

Storage options for extracellular vesicles (EVs) remain limited, constraining their clinical and research applications. Conventional low-temperature freezing (-80 °C), although the established standard, requires substantial resources and presents logistical challenges....

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Cite This Study

Woo et al. (2026) studied this question.

synapsesocial.com/papers/69c620be15a0a509bde1954f https://doi.org/10.1039/d6lc00014b

View Full Paper

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Rapid Desiccation and On-disc Rehydration of Extracellular Vesicles for Non-cryogenic Preservation

Key Points

Implication

Abstract

Discussion

Cite This Study

Rapid Desiccation and On-disc Rehydration of Extracellular Vesicles for Non-cryogenic Preservation

Key Points

Implication

Abstract

Discussion

Cite This Study

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