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March 27, 2026Kidney International ReportsOpen Access

OUTLOOK study evaluates polypharmacy and prescribing patterns in older Australian patients with kidney failure.

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Why the study?

Polypharmacy is common in older adults and linked to adverse outcomes, but prescribing patterns and polypharmacy extent in older patients with kidney failure are not well documented.

What are the prescribing patterns and extent of polypharmacy in older patients with kidney failure?

Population

Older patients with kidney failure in Australia enrolled in the OUTLOOK study

Key result

Medication use and polypharmacy among older Australian patients with kidney failure are being evaluated in the OUTLOOK study to address the lack of documentation regarding prescribing patterns.

Authors

ASAmanda N. SiriwardanaUNSW SydneyNGNicholas GraySunshine Coast University HospitalAMAngela MakrisLiverpool Hospital

Discussion

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Overview

Encourages routine polypharmacy review in older kidney failure patients; extends limited prescribing evidence and leaves optimal deprescribing strategies open.

Key Points

  • The analysis aims to document prescribing patterns and the prevalence of polypharmacy in older adults with kidney failure.
  • Analyzed medication use among older adults with kidney failure
  • Utilized data from the OUTLOOK study conducted in Australia
  • Focused on prescribing patterns and polypharmacy prevalence
  • Polypharmacy is highly prevalent in the studied population
  • Prescribing patterns showed variability among patients
  • Identified potential adverse health outcomes associated with polypharmacy

Structured PICO

What are the prescribing patterns and extent of polypharmacy in older patients with kidney failure?

P
Population
Older patients with kidney failure in Australia
O
Outcome
Prescribing patterns and extent of polypharmacy

Cite This Study

Siriwardana et al. (2026) studied this question. Medication use and polypharmacy among older Australian patients with kidney failure are being evaluated in the OUTLOOK study to address the lack of documentation regarding prescribing patterns.

synapsesocial.com/papers/69c6210b15a0a509bde199ffhttps://doi.org/10.1016/j.ekir.2026.104954
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prescribing patterns in older people with advanced chronic kidney disease towards the end of life2024 · 2 citations
  2. 2International prescribing patterns and polypharmacy in older people with advanced chronic kidney disease: results from the European Quality study2020 · 47 citations
  3. 3EVALUATION OF PRESCRIBING PATTERN AND IMPACT OF POLYPHARMACY IN GERIATRIC PATIENTS WITH CHRONIC KIDNEY DISEASE2026
  4. 4EVALUATION OF PRESCRIBING PATTERN AND IMPACT OF POLYPHARMACY IN GERIATRIC PATIENTS WITH CHRONIC KIDNEY DISEASE2026
  5. 5Polypharmacy, renal insufficiency and elder care: a systematic review2020 · 2 citations