Apolipoprotein AI is a protective factor for idiopathic sudden sensorineural hearing loss: a two-sample mendelian randomisation study

Key Points

• This research aims to investigate the causal effect of ApoAI levels on the risk of idiopathic sudden sensorineural hearing loss (ISSNHL).
• Conducted a two-sample Mendelian randomisation analysis.
• Assessed the relationship between ApoAI levels and ISSNHL risk.
• Utilized genetic data to infer causality.
• Higher levels of ApoAI were linked to a reduced risk of developing ISSNHL.
• Findings suggest a protective factor role for ApoAI against hearing loss.