WCN26-5527 LGALS3 induces ferroptoisis via interaction of autophagy in CKD vascular calcification

Liming Huang; Guoli Li; Yi Li; Guisen Li; Li Wang

doi:10.1016/j.ekir.2026.104239

March 25, 2026Kidney International ReportsOpen Access

WCN26-5527 LGALS3 induces ferroptoisis via interaction of autophagy in CKD vascular calcification

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Key Points

To explore how LGALS3 induces ferroptosis through autophagy in the context of vascular calcification in chronic kidney disease (CKD).
Analyzed the interaction of LGALS3 with autophagy pathways.
Examined the role of BRG1 and ABHD17 in vascular smooth muscle cells (VSMCs).
Investigated the effects of protein S-palmitoylation on vascular calcification.
Identified ABHD17B as a potential target for preventing vascular calcification.
Demonstrated that the Cys1205 residue of BRG1 plays a key role in modulating procalcification effects.
Found a strong correlation between protein S-palmitoylation and vascular calcification in CKD.

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Implication

Demonstrates the role of LGALS3 in inducing ferroptosis in CKD vascular calcification, suggesting new therapeutic targets.

Abstract

Interestingly, the Cys1205 residue of BRG1 is involved in the interaction between ABHD17 and BRG1 and affects its synergistic procalcification effect on VSMCs.Conclusion: Protein S-palmitoylation modification is closely associated with vascular calcification in CKD, and ABHD17B might be a novel potential target for the prevention and treatment of vascular calcification in CKD.I have potential conflict of interest to disclose.

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Cite This Study

Huang et al. (2026) studied this question.

synapsesocial.com/papers/69c76fff8bbfbc51511e0671 https://doi.org/10.1016/j.ekir.2026.104239

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WCN26-5527 LGALS3 induces ferroptoisis via interaction of autophagy in CKD vascular calcification

Key Points

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Implication

Abstract

Discussion

Cite This Study

WCN26-5527 LGALS3 induces ferroptoisis via interaction of autophagy in CKD vascular calcification

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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