WCN26-3223 Impact of Body Mass Index on Renal and Cardiovascular Outcomes in Japanese Autosomal Dominant Polycystic Kidney Disease

Results: SRC is frequently associated with scleroderma-specific autoantibodies, such as anti-RNA polymerase III antibodies.Seronegative diffuse SSc typically manifests as a milder disease; and cases with SRC progressing to end-stage renal failure requiring hemodialysis, as in this report, are rare.Anti-SSSCA1 antibodies have been implicated in systemic scleroderma and Sjgren's syndrome, but there are no previous case reports or series linking these antibodies to SRC.The clinical implications of anti-SSSCA1 antibodies remain poorly understood.The rapid deterioration of the patient's renal function due to SRC may be related to anti-SSSCA1 antibodies.Conclusion: Diffuse SSc with anti-SSSCA1 antibodies may be associated with severe SRC.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.