Healthcare utilization and costs associated with changes in medication adherence around the 80% threshold in patients with cardiovascular disease

Samuel K. Peasah; Tiffany Lee; Yan Huang; Angela Inneh; Urvashi Patel; Chester B. Good

doi:10.1016/j.japh.2026.103104

March 1, 2026Journal of the American Pharmacists AssociationOpen Access

Healthcare utilization and costs associated with changes in medication adherence around the 80% threshold in patients with cardiovascular disease

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Key Points

This analysis aims to assess how changes in medication adherence around the 80% threshold affect healthcare utilization and costs for patients with cardiovascular disease.
Conducted a retrospective observational analysis of claims data from January 2021 to June 2023.
Included patients aged 50-80 years with a history of cardiovascular disease and cardiometabolic medications.
Categorized patients into adherence groups based on pre-and post-index medication adherence levels using the proportion of days covered (PDC).
Measured outcomes included total cost-of-care per member per year and cardiovascular-related emergency department visits.
Most patients in the heart failure and direct oral anticoagulants groups were aged 70 or older, while those on antidiabetics and antiplatelets were mostly in their 60s.
Patients transitioning to higher adherence groups generally experienced lower total costs compared to those with lower adherence.
Total cost-of-care increased for patients moving from an adherence level of 90% and above to below 90% across all medication classes.

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Implication

Observational analysis evaluates cost differences linked to medication adherence levels in older adults with cardiovascular disease, suggesting improved adherence can lower costs.

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Cite This Study

Peasah et al. (2026) studied this question.

synapsesocial.com/papers/69c770418bbfbc51511e0767 https://doi.org/10.1016/j.japh.2026.103104

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Healthcare utilization and costs associated with changes in medication adherence around the 80% threshold in patients with cardiovascular disease

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Healthcare utilization and costs associated with changes in medication adherence around the 80% threshold in patients with cardiovascular disease

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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