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March 25, 2026Kidney International ReportsOpen Access

Wcn26-6471 Bevacizumab-Associated Kidney Toxicity in Oncology Patients: An Onconephrology Perspective From a Multi-Ethnic Cohort in Southeast Asia

Jia Yee Wong Jia Yee Wong Han Hwa Lee Y. C. Hooi Megan Chong Jing Yi Uma Devi Markandan Carven Lit Kar Wen Marniza Binti Saad Soo Kun Lim Chew Ming Wong

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Key Points

To explore the kidney toxicity associated with bevacizumab in oncology patients, particularly focusing on electrolyte disturbances.
Case analysis of a multi-ethnic cohort
CT scans and urine studies to assess electrolyte levels
Hormonal assays to evaluate corticosteroid and ACTH levels
Dexamethasone suppression test to confirm Cushing syndrome
Severe hypokalemia (2.3 mmol/L) and alkalosis observed after chemotherapy/immunotherapy treatment
Recurrence of hyponatremia identified alongside hypercortisolism
Electrolyte shifts suggest dual paraneoplastic syndrome potentially linked to small cell lung cancer
Normalization of sodium levels achieved through fluid restriction and salt tablets

Implication

Observational case highlights kidney toxicity and electrolyte shifts in oncology patients, suggesting complex hormonal interactions.

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Cite This Study

Wong et al. (2026) studied this question.

synapsesocial.com/papers/69c770418bbfbc51511e0837 https://doi.org/10.1016/j.ekir.2026.105968

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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