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March 25, 2026Kidney International ReportsOpen Access

Wcn26-8430 Immune Efflux Signatures Define Il-17-Dependent Mechanisms of Treatment Resistance in Lupus Nephritis

Kritika Singh Upendra Rathore Harshit Singh NARAYAN PRASAD Vikas Agarwal

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Key Points

To evaluate the role of the IL-17/TAK-1/C/EBP pathway in P-glycoprotein expression and treatment resistance in lupus nephritis.
Analyzed P-gp expression in plasma cells and Th17 cells from lupus nephritis patients.
Treated U266B1 plasma cells with IL-17, IL-6, and their inhibitors for 24 hours.
Quantified plasma levels of key cytokines and chemokines using ELISA.
Elevated frequencies of P-gp expressing plasma cells and Th17 cells observed in refractory and active lupus nephritis.
Significant reduction in P-gp+ cells after 3 months of standard therapy compared to baseline.

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Implication

Evaluation of IL-17 pathways reveals mechanisms of treatment resistance in lupus nephritis, suggesting potential therapeutic targets.

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Cite This Study

Singh et al. (2026) studied this question.

synapsesocial.com/papers/69c770888bbfbc51511e08d0 https://doi.org/10.1016/j.ekir.2026.105831

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1P-Glycoprotein induction in Plasma cells drives treatment resistance in Lupus Nephritis via IL-17/TAK-1/C/EBP-β pathway 2258946Original Research · 2026
21012 Deep peripheral blood immunophenotyping identifies a subgroup of lupus nephritis patients characterized by high type 1 interferon signaling, persistent activated immune cells and poor renal response to standard of care at 1 year2024
3Interferon and B-cell Signatures Inform Precision Medicine in Lupus Nephritis2024 · 27 citations
4<i>In silico</i> analysis highlights elevation of epithelial-to-mesenchymal transition characteristics in non-responding lupus nephritis patients2025
5O23 Interferon upregulation and B and plasma cell gene dysregulation patterns reveal three distinct lupus nephritis subgroups with differential anticipated response to targeted therapies2024

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Single-cell profiling unveils nephritis-related circulating immunological signatures in systemic lupus erythematosus patients2026

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