The novel ultrasound-based sniff test demonstrated high sensitivity, specificity, and overall accuracy for screening central venous stenosis in end-stage kidney disease patients on hemodialysis.
RCT
Crossover
Does post-dilution hemodiafiltration alter the intradialytic kinetics of cardiac biomarkers compared to high-flux hemodialysis in patients without acute CVD?
Hemodiafiltration significantly reduces concentrations of hs-cTnI, hs-cTnT, and NT-proBNP compared to conventional hemodialysis, emphasizing the need to consider dialysis clearance when using these biomarkers diagnostically.
Conclusion:The novel ultrasound-based sniff test demonstrates promising diagnostic performance in screening for central venous stenosis in end-stage kidney disease patients on long-term hemodialysis, with high sensitivity, specificity, and overall accuracy.Given its non-invasive nature and accessibility, it may serve as a useful preliminary tool for identifying patients requiring further confirmatory imaging via angiography, particularly in resource-limited settings.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
Drivsholm et al. (2026) conducted an RCT in End-stage kidney disease. Ultrasound-based sniff test vs. Angiography was evaluated on Diagnostic performance for central venous stenosis. The novel ultrasound-based sniff test demonstrated high sensitivity, specificity, and overall accuracy for screening central venous stenosis in end-stage kidney disease patients on hemodialysis.
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