What question did this study set out to answer?

The aim is to assess the effects of Auricularia fuscosuccinea on renal function in diabetic kidney disease.

March 28, 2026Open Access

Wcn26-3361 Guideline-Directed Medical Therapies for Diabetic Kidney Disease Among Thai People With Type 2 Diabetes: A Real-World Data Based on Theptarin Diabetes Staging

Key Points

The aim is to assess the effects of Auricularia fuscosuccinea on renal function in diabetic kidney disease.
Adult Wistar rats were used for the experiment.
Three groups were formed: control, T2DM induction, and T2DM treated with Auricularia fuscosuccinea.
Renal function was assessed via serum creatinine and inulin clearance.
Oxidative stress was evaluated through urinary peroxides, thiols, and catalase levels.
T2DM rats treated with Auricularia fuscosuccinea had significantly lower serum creatinine levels.
Inulin clearance improved in the treated group compared to T2DM rats.
Reduction in urinary peroxides and increased thiol and catalase levels were observed in the treatment group.

Abstract

kidney disease (DKD) in order to evaluate its impact on renal function.Objective: evaluate the renoprotective effect of the AF in DKD in rats.Methods: Adult Wistar rats were divided into three groups: Controlvehicle (0.1M citrate buffer, 60mg/kg, i.p.); T2DM -T2DM induction (nicotinamide, 100mg/kg, intraperitoneal, i.p. + streptozotocin, diluted in 0.1M citrate buffer, 60mg/kg, i.p., once).and T2DM+AF -Auricularia fuscosuccinea (AF, 100mg/kg, diluted in 1mL of drinking water, orally, once a day, 30 days) in T2DM rats.Evaluation of renal function by serum creatinine and inulin clearance (Clin) and oxidative profile by urinary peroxides (FOX), thiols and catalase were evaluated.Results: The treated group, T2DM+AF, presented a reduction in serum creatinine (0.290.03 vs 1.020,30, p<0.05) and an increased inulin clearance (0.790.50 vs 0.300.03,p<0,05) compared with the T2DM group.Also, the oxidative profile of the T2DM+AF group showed a reduction in urinary peroxides (0.110.20 vs 12.01.8nmol/gcreat, p<0.05) and elevation in the thiol (18.96.0 vs 1.60.6 nmol/g, p<0.05) and catalase levels (6.721.39vs 0.400.01umg/ml, p<0.05) compared with T2DM group.Conclusion: This is the first study to point out the therapeutical properties of the amazonian mushroom Auricularia fuscosuccinea (AF).The oral administration of AF showed renoprotective effects in renal function and attenuation of the oxidative damage, confirming its antioxidant properties in the DKD.Our findings demonstrate that consuming AF daily shows additional beneficial effects in the treatment, protecting renal function from the insults of the T2DM.Further studies are needed to assess long-term outcomes regarding its new product.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.

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