Adhesion molecules provide an endothelial protein signature in preclinical and clinical Alzheimer’s disease and predict clinical progression

Key Points

• This research aims to identify protein signatures related to vascular adhesion in Alzheimer's disease and their potential role in predicting disease progression.
• Analyzed cerebrospinal fluid (CSF) samples for vascular adhesion proteins.
• Compared protein levels in preclinical and clinical stages of Alzheimer's disease.
• Conducted correlation analysis with disease pathology.
• Identified a distinct signature of vascular adhesion proteins associated with Alzheimer's pathology.
• Elevated levels of these proteins were observed even in preclinical Alzheimer's disease stages.
• The findings suggest a potential for using these proteins as predictive biomarkers for disease progression.