Wcn26-4837 Kidney Outcomes at 1 Year of Corrected Age in Preterm Neonates Born Before 34 Weeks of Gestation: A Cohort Study

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Key Points

This analysis investigates the effects of corticosteroid use on kidney-related adverse events in preterm neonates.
Conducted a post hoc analysis using two datasets: JNR-IgAN 2019 and J-IGACS 2023.
Stratified cohorts by corticosteroid use, comparing users and non-users.
Applied overlap weighting to address baseline imbalances.
Employed negative binomial regression to estimate IRRs for primary and secondary outcomes.
95 primary outcome events reported in JNR-IgAN 2019 and 103 in J-IGACS 2023 cohorts.
Pooled IRR for primary outcome was 3.25, indicating a higher risk for corticosteroid users.
Corticosteroid use linked to increased infection risks (pooled IRR: 6.99) and new-onset diabetes (pooled IRR: 26.7).
Reduced risk of cerebrovascular and cardiovascular events in corticosteroid-treated patients (pooled IRR: 0.02).

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Cohort analysis examines adverse outcomes in preterm neonates receiving corticosteroids, suggesting cautious use based on age.

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Krishnasamy et al. (2026) studied this question.

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