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This research examines the protective effects of Panax notoginseng saponins on cognitive impairment caused by gp120, focusing on underlying mechanisms.

March 28, 2026Journal of Pharmacy and Pharmacology0 citations

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Protective effects and mechanisms of Panax notoginseng saponins against gp120-induced cognitive impairment: a network pharmacology and metabolomics study

MHMingyu HuangGuangxi Medical University YZY F ZhouGuangxi Medical University SLShanshan LiSouth China Agricultural University

Key Points

This research examines the protective effects of Panax notoginseng saponins on cognitive impairment caused by gp120, focusing on underlying mechanisms.
Investigated neuroprotective effects of Panax notoginseng saponins
Utilized network pharmacology and metabolomics approaches
Analyzed modulation of the NOD-like receptor signaling pathway
Demonstrated neuroprotection against gp120-induced cognitive impairment
Showed suppression of neuroinflammation
Inhibited apoptosis in neural cells

Abstract

PNS confers neuroprotection against gp120-induced cognitive impairment by modulating the NOD-like receptor signaling pathway, which suppresses neuroinflammation and inhibits apoptosis.

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Protective effects and mechanisms of Panax notoginseng saponins against gp120-induced cognitive impairment: a network pharmacology and metabolomics study

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