Wnt5a‐Induced Exosomes From Bone Marrow Mesenchymal Stem Cells Promote Spinal Cord Injury Repair by Modulating Immune Cell Phenotypes and Alleviating Neuroinflammation via the NF ‐ κB Pathway

Da Luo; Enhui Feng; Ling Chen; Ke Ni; Sheng Luo; Lin Ma; Yuting Wu; Zhifeng Hu; Dongliang Lin; Binshan Zhang; Chaoyi Yin; Da Guo; Chaolun Liang; Xing Li

doi:10.1002/cns.70834

March 26, 2026CNS Neuroscience & TherapeuticsOpen Access

Wnt5a‐Induced Exosomes From Bone Marrow Mesenchymal Stem Cells Promote Spinal Cord Injury Repair by Modulating Immune Cell Phenotypes and Alleviating Neuroinflammation via the NF ‐ κB Pathway

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Key Points

This research aims to investigate how Wnt5a-induced exosomes affect spinal cord injury repair mechanisms.
Examine the role of Wnt5a in bone marrow mesenchymal stem cell (BMSC) exosome production.
Analyze the modulation of immune cell phenotypes by these exosomes.
Assess the impact on neuroinflammation via NF-κB pathway inhibition.
Wnt5a significantly enhances the neuroregenerative potential of BMSC-derived exosomes.
Exosomes alter immune cell phenotypes favorably for repair processes.
Inhibition of the NF-κB pathway correlates with reduced neuroinflammation.

Implication

Wnt5a-induced exosomes improve spinal cord injury repair by modulating immune responses, suggesting new treatment strategies.

Abstract

Collectively, these findings indicate that Wnt5a enhances the neuroregenerative potential of BMSC-Exos by modulating immune responses and suppressing neuroinflammation, likely through inhibiting the NF-κB signaling pathway.

Discussion

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Cite This Study

Luo et al. (2026) studied this question.

synapsesocial.com/papers/69c771988bbfbc51511e191d https://doi.org/10.1002/cns.70834

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Wnt5a‐Induced Exosomes From Bone Marrow Mesenchymal Stem Cells Promote Spinal Cord Injury Repair by Modulating Immune Cell Phenotypes and Alleviating Neuroinflammation via the NF ‐ κB Pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

Wnt5a‐Induced Exosomes From Bone Marrow Mesenchymal Stem Cells Promote Spinal Cord Injury Repair by Modulating Immune Cell Phenotypes and Alleviating Neuroinflammation via the NF ‐ κB Pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

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