Analogs of p-coumaric acid demonstrate varying antioxidant properties based on their chemical structure, indicating potential applications.
A series of p-coumaric acid analogs, 3-substituted 4-hydroxycinnamic acids with electron-withdrawing (II: 3-NO2, III: 3-F) and electron-donating (IV: 3-CH3, V: 3-OCH3) substituents are utilized to demonstrate the relationship between their chemical structures and antioxidant properties. Using the ABTS/HRP/H2O2 method, the relative decolorization concentration DC50 (dose to scavenge 50% of the free radical) for I-V were determined and found to correlate with electronic substituent effects.
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Colmenares et al. (2009) studied this question.
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