In Vivo Effect of a Synthetic Amniotic Fluid on Fetal Lung and Gastrointestinal Tract: A Pre‐Clinical Rodent Model

Key Points

• To evaluate the effect of synthetic amniotic fluid on fetal lung and gastrointestinal tract development in a rodent model.
• Used a pre-clinical rodent model for intervention.
• Administered synthetic amniotic fluid and compared with normal saline and lactated Ringer's solution.
• Measured lung inflammation and surfactant expression levels.
• Synthetic amniotic fluid reduced lung inflammation significantly compared to controls.
• Enhanced surfactant expression was observed with synthetic amniotic fluid relative to normal saline and lactated Ringer's solution.
• Minimal gastrointestinal effects were noted with the synthetic amniotic fluid.