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This report aims to highlight a rare case of immune-related cholecystitis following treatment with ICIs.

Immune-related cholecystitis following combination therapy with nivolumab and ipilimumab in a patient with metastatic melanoma: a case report and literature review

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This report aims to highlight a rare case of immune-related cholecystitis following treatment with ICIs.
Detailed clinical evaluation of the patient following combination therapy with nivolumab and ipilimumab.
Laboratory evaluation and imaging studies to confirm cholecystitis.
Administration of conservative management including hydration and antibiotics.
Utilization of corticosteroid therapy due to inadequate response to initial treatment.
The patient experienced acute gastrointestinal symptoms and fever shortly after treatment.
Imaging confirmed cholecystitis without gallstones, indicating a rare irAE.
Corticosteroid therapy led to rapid clinical improvement after conservative management was insufficient.

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A case report reveals immune-related cholecystitis in melanoma patients, suggesting careful monitoring for rare side effects.

Gkoufa et al. (2026) studied this question.

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