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Demonstrates how to derive the pH at which nitrosation is maximized in aqueous solutions, highlighting implications for nitrosamine control.
The rate of nitrosation of a simple secondary amine in aqueous solution is greatest at the pH that maximizes the total solution content of nitrous acid and free-base (unprotonated) secondary amine. The value of this pH, designated as pHmax,can be easily derived through consideration of the equilibria involved. The derivation of pHmax as given demonstrates that it is possible to predict from first principles some significant aspects of nitrosation kinetics. The importance of understanding pHmax with respect to promoting or avoiding nitrosamine formation is discussed.
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Gernon et al. (2003) studied this question.
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