This research demonstrates that Stachys pilifera extracts reduce inflammation in macrophages, suggesting therapeutic potential in chronic diseases.
By downregulating NF-κB activity, S. pilifera Benth. effectively modulates the expression of key proinflammatory mediators, including inducible NO synthase (iNOS) and COX-2, ultimately leading to reduced NO and PGE₂ production. These findings suggest that S. pilifera Benth. may exert its anti-inflammatory effects through inhibition of the NF-κB signaling pathway, offering potential therapeutic applications in the management of chronic inflammatory diseases.
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Salehpour et al. (2026) studied this question.
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