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This application simulates chromatographic optimization, improving mobile phase composition using the simplex algorithm.
A spreadsheet application for chromatographic optimization using the sequential Simplex algorithm is described. The Excel application simulates a chromatographic optimization where the composition of a mobile phase calculated by the Simplex method is evaluated with a previously defined chromatographic optimization function (COF) of known maximum value.
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Gregorio Cruz (2018) studied this question.
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