IL‐15 Plus Thymosin α1 Reduces Senescent Hepatic CD8 + T Cells in Hepatocellular Carcinoma via PI3K/AKT Suppression
Key Points
This research aims to investigate how IL-15 and thymosin α1 therapy affects senescent CD8+ T cells in hepatocellular carcinoma.
Administered combined IL-15 and thymosin α1 therapy
Monitored changes in CD8+ T cell senescence
Analyzed the PI3K/AKT signaling pathway
IL-15 plus thymosin α1 decreased CD8+ T cell senescence
Enhanced antitumor immunity observed
Suppression of PI3K/AKT signaling pathway confirmed
Abstract
Combined IL-15 and Tα1 therapy reverses CD8+ T cell senescence and enhances antitumor immunity in HCC through suppression of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway.