Why the study?
Does sildenafil provide clinical benefit in individuals with a Fontan circulation?
Does sildenafil provide clinical benefit in individuals with a Fontan circulation?
Retrospective registry data suggests a potential benefit of sildenafil in patients with Fontan circulation, highlighting the need for prospective clinical trials.
Sildenafil should not yet change Fontan practice; observational data leaves open possible benefit and calls for RCTs.
Some individuals with a Fontan circulation may benefit from sildenafil. Adequately designed clinical trials are needed.
No takes yet. Share an insight, caveat, or question.
Rueter et al. (2024) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: