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March 29, 2026JACC Advances0 citationsOpen Access

Lp(a) Has Specific Effects on Coronary Artery Disease Independent of LDL-C

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MLMoa P. LeeUniversity of North Carolina at Chapel HillSKSarah H. KoenigsbergUniversity of North Carolina at Chapel HillMAMohammad Yaser AnwarUniversity of North Carolina at Chapel Hill

Key Points

  • The research aims to determine the independent effects of Lp(a) on coronary artery disease and type 2 diabetes.
  • Analyzed causal relationships between Lp(a) levels and coronary artery disease
  • Evaluated HbA1c levels in relation to Lp(a) exposure
  • Stratified cardiovascular risk thresholds by ancestry
  • Increased Lp(a) levels are causally linked to coronary artery disease
  • Very low Lp(a) exposure does not correlate with type 2 diabetes
  • Optimal thresholds for cardiovascular risk are below 125/105 nmol/L for both European and African ancestries.

Abstract

Increasing Lp(a) exposure had direct, independent causal effects on coronary artery disease and HbA1c only; very low Lp(a) exposure is suggested to not be causally associated with type 2 diabetes. The optimal European and African ancestry threshold to stratify cardiovascular risk is comparable, and below 125/105 nmol/L in current U.S./European medical professional society guidelines.

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Cite This Study

Lee et al. (2026) studied this question.

synapsesocial.com/papers/69c8c115de0f0f753b39b9e8https://doi.org/10.1016/j.jacadv.2026.102697
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