Nishimura et al demonstrate that NUTM1 fusion genes induce leukemia in hematopoietic progenitors, suggesting a critical mechanism in infant leukemia.
In this issue of Blood, Nishimura et al 1 demonstrate that expression of NUTM1 fusion genes in hematopoietic progenitors can induce a "one-hit leukemia" by driving differentiation to highly proliferating, stem-like B-cell progenitors.
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Shiloh et al. (2026) studied this question.
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