This analysis demonstrates effective localization of tDCS targets in drug-resistant epilepsy, suggesting improved treatment outcomes.
Key Points
The aim is to create a non-invasive method to accurately localize targets for transcranial direct current stimulation in patients with drug-resistant epilepsy.
Utilized interictal scalp EEG to estimate brain connectivity in the source space.
Developed a dynamic EEG source network based on neural mass models for target localization.
Employed SimNIBS simulations to optimize target location for tDCS.
Used intracranial EEG data from 18 patients to validate the proposed procedure.
The localized target matched with the resected brain area in 80% of seizure-free patients.
Only 37.5% of non-seizure-free patients had the localized target match.
Significant reduction in seizure likelihood observed with cathodal stimulation at the target compared to non-target locations.
Highlighting the critical role of selecting low-noise segments for improved performance.