Findings demonstrate the importance of sputum cytology in assessing airway inflammation in severe asthma, suggesting better treatment strategies.
Extract Severe asthma is a heterogeneous condition requiring multifaceted management. Inhaled corticosteroids (ICS) remain the cornerstone of treatment; however, some patients remain uncontrolled or exhibit ICS resistance, necessitating biologic therapy. While biologics primarily target type 2 (T₂)-driven inflammation, some exhibit non-T₂, often neutrophilic, airway inflammation [1]. Accurate assessment of airway inflammation is crucial for precision medicine and phenotype-based treatment in severe asthma [1, 2].
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Khan et al. (2026) studied this question.
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