Key result
Higher ultrasound-derived carotid biomechanical indicators linked to greater atherosclerotic stenosis severity.
Why the study?
Biomechanical properties of the arterial wall underlie arterial disease development, prompting investigation into alterations and relationships among stiffness index, circumferential stress, longitudinal stress, and shear modulus in carotid artery disease.
Do ultrasound-derived biomechanical indices correlate with the severity of atherosclerotic carotid artery stenosis in adult males?
Cross-Sectional (n=136)
Do ultrasound-derived biomechanical indices correlate with the severity of atherosclerotic carotid artery stenosis in adult males?
Ultrasound-derived biomechanical indices, including shear modulus and wall stress, significantly increase with carotid stenosis severity, offering a potential non-invasive tool for assessing atherosclerotic plaque vulnerability.
May facilitate noninvasive carotid plaque vulnerability assessment; hypothesis-generating pending prospective outcome validation.
The biomechanical condition and properties of the arterial wall illustrate a crucial principle regarding the basis and development of arterial diseases. This study aimed to investigate indicators such as stiffness index (β), circumferential stress (CSmean), longitudinal stress (LSmean), and shear modulus (SMmean) alterations of the left common carotid artery in human individuals afflicted with atherosclerotic carotid artery disease, in order to determine the relationship among the mentioned indicators. The current study introduced methods for tracing simultaneous alterations in the lumen and inter-adventitial diameters, intima–media thickness, longitudinal movement, and velocity of the left common carotid artery (CCA). The mentioned parameters were measured in 136 male subjects, classified into four groups: control (n = 35), mild (n = 34), moderate (n = 34), and severe (n = 33) stenosis, in a cross-sectional design using B-mode and Doppler ultrasound systems. These basic parameters were used to calculate the mentioned biomechanical indicators. There was a significant increasing trend for the above-mentioned biomechanical indicators of the CCA from the control to the severe stenosis group (p < 0.05). In addition, the results of the present study illustrated a significant relationship between SMmean and β, CSmean, and LSmean in subjects with various degrees of stenosis (p < 0.05). We conclude that indicators such as SMmean, β, CSmean, and LSmean could be beneficial for assessing atherosclerotic human carotid arteries and may also provide important information for physicians regarding appropriate therapeutic strategies, including interventional examination, balloon angioplasty, stent deployment, graft replacement, and discrimination of vulnerable plaques from others.
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Ghahremani et al. (2026) conducted a cross-sectional in Atherosclerotic carotid artery disease (n=136). Ultrasound biomechanical evaluation vs. Healthy controls was evaluated on Alterations in biomechanical indicators (stiffness index, circumferential stress, longitudinal stress, and shear modulus) across stenosis severity groups (p=<0.05). Ultrasound-derived biomechanical indicators of the common carotid artery, including shear modulus, stiffness index, circumferential stress, and longitudinal stress, significantly increased with the severity of atherosclerotic stenosis (p<0.05).
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