Flow Orientation as a Critical Parameter in Nanoscale Membrane Filtration for Optimising Small Extracellular Vesicle Isolation

Sadeka Nujhat; Hannah S. Leese; Madeleine Strickland; Mirella Di Lorenzo; Sandhya Moise

doi:10.1039/d6na00035e

January 1, 2026Nanoscale AdvancesOpen Access

Flow Orientation as a Critical Parameter in Nanoscale Membrane Filtration for Optimising Small Extracellular Vesicle Isolation

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Key Points

The research aims to evaluate how flow orientation affects membrane filtration efficiency for isolating small extracellular vesicles.
Analyzed performance of tangential and perpendicular flow geometries in membrane filtration.
Assessed fouling rates and membrane flux under varying conditions.
Conducted experiments with biological nanoparticles to compare outcomes.
Identified significant differences in flux rates between flow geometries.
Demonstrated that specific orientations reduce fouling effectively.
Quantified enhanced isolation efficiency of extracellular vesicles through optimized flow configurations.

Implication

Membrane filtration demonstrates optimization of small extracellular vesicle isolation, indicating performance trade-offs.

Abstract

Membrane filtration of biological nanoparticles typically employs tangential or perpendicular flow geometries, each presenting inherent performance trade-offs between membrane flux and fouling. While these configurations involve established limitations in transmembrane...

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Cite This Study

Nujhat et al. (2026) studied this question.

synapsesocial.com/papers/69c8c214de0f0f753b39c3d9 https://doi.org/10.1039/d6na00035e

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Flow Orientation as a Critical Parameter in Nanoscale Membrane Filtration for Optimising Small Extracellular Vesicle Isolation

Key Points

Implication

Abstract

Discussion

Cite This Study

Flow Orientation as a Critical Parameter in Nanoscale Membrane Filtration for Optimising Small Extracellular Vesicle Isolation

Key Points

Implication

Abstract

Discussion

Cite This Study

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