Fibroblast Growth Factor 21 and Cardiometabolic Risk Markers in Metabolically Healthy and Unhealthy Obese Children

Q: What does this research mean for the field?

Although FGF21 levels are elevated in metabolically unhealthy obese children compared to metabolically healthy obese children and healthy controls, FGF21 does not appear to be a reliable biomarker for cardiometabolic risk. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Can Kurşun; Zühal Örnek; Berrak Güven; Banu Alıcıoğlu

doi:10.1111/jpc.70375

March 26, 2026Journal of Paediatrics and Child Health

Fibroblast Growth Factor 21 and Cardiometabolic Risk Markers in Metabolically Healthy and Unhealthy Obese Children

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Key Points

To investigate the relationship between FGF21 levels and cardiometabolic risk markers in children with differing obesity types.
Compared FGF21 levels in children with metabolically unhealthy obesity (MUO), metabolically healthy obesity (MHO), and healthy controls.
Conducted statistical analyses to evaluate differences in biomarker levels among the groups.
FGF21 levels were significantly higher in children with MUO compared to MHO and healthy controls.
FGF21 is not a reliable biomarker for categorizing obesity types.

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Implication

Reports elevated FGF21 levels in metabolically unhealthy obese children, indicating potential biomarker challenges.

Abstract

FGF21 levels were elevated in children with MUO compared with children with MHO and healthy controls. However, FGF21 does not appear to be a reliable biomarker. Further studies are required to clarify this relationship.

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Cite This Study

Kurşun et al. (2026) studied this question.

synapsesocial.com/papers/69c8c247de0f0f753b39c798 https://doi.org/10.1111/jpc.70375

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Fibroblast Growth Factor 21 and Cardiometabolic Risk Markers in Metabolically Healthy and Unhealthy Obese Children

Key Points

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Implication

Abstract

Discussion

Cite This Study

Fibroblast Growth Factor 21 and Cardiometabolic Risk Markers in Metabolically Healthy and Unhealthy Obese Children

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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