Diverse synthesis of thioamides shows high functional group tolerance in a convenient water-based method.
We present a diverse synthesis of thioamides by installing elemental sulfur and amines in nitroethane via umpolung C-N bond formation. The uniqueness of this water-based protocol renders it more convenient for thioamide synthesis at room temperature. These mild reaction conditions ensure wide functional group tolerance, facilitating late-stage functionalization of drug scaffolds, including intermediates relevant to active pharmaceutical ingredient (API) synthesis.
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Bhatt et al. (2026) studied this question.
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