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This research assesses whether early PET response can predict relapse risk in large B-cell lymphoma patients after 2L CAR T therapy.

March 29, 2026Blood AdvancesOpen Access

Early PET response predicts the risk of relapse after 2L axi-cel in large B-cell lymphoma

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Authors

AKAndrea KühnlKing's College Hospital NHS Foundation Trust AKAmy A KirkwoodCRUK Lung Cancer Centre of Excellence MNMichael NorthendUniversity College London Hospitals NHS Foundation Trust

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Implication

Observational analysis examines early FDG PET response predicting relapse risk in large B-cell lymphoma, suggesting early therapies for high-risk patients.

Key Points

This research assesses whether early PET response can predict relapse risk in large B-cell lymphoma patients after 2L CAR T therapy.
Analyzed a national cohort of 302 large B-cell lymphoma patients receiving 2L axi-cel.
Assessed FDG PET responses at 1 month post-treatment using the Deauville score categories.
Evaluated progression-free survival and overall survival based on PET response and pre-infusion LDH levels.
Patients with Deauville scores of 4 and 5 had a 50% and 73% risk of progression by 6 months, compared to 25% for scores 1-3.
The hazard ratios for DS4 and DS5 were 3.07 and 5.20 respectively, indicating significantly higher risk of relapse.
A risk model combining DS categories and LDH levels identified a high-risk group with over 70% risk of early failure.

Cite This Study

Kühnl et al. (2026) studied this question.

synapsesocial.com/papers/69c8c277de0f0f753b39cb90 https://doi.org/10.1182/bloodadvances.2026019802

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Implication

Observational analysis examines early FDG PET response predicting relapse risk in large B-cell lymphoma, suggesting early therapies for high-risk patients.

Early PET response predicts the risk of relapse after 2L axi-cel in large B-cell lymphoma

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Implication

Key Points

Cite This Study

Early PET response predicts the risk of relapse after 2L axi-cel in large B-cell lymphoma

Discussion

Member takes

Implication

Key Points

Cite This Study

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