Metallothionein Safeguards Hepatic Zn‐Fe Homeostasis and Restrains Yap‐Driven Hepatic Fe Overload to Protect Against Chronic Liver Fibrosis

Key Points

• The research investigates the role of metallothionein in maintaining trace-metal balance and its influence on Yap signaling to prevent liver fibrosis.
• Examined the role of metallothionein in hepatocytes.
• Analyzed zinc and iron homeostasis in liver tissue.
• Assessed Yap signaling pathways in liver fibrosis models.
• Metallothionein effectively maintains zinc and iron levels in the liver.
• Enhancing metallothionein activity reduces Yap-driven iron overload.
• Combining zinc supplementation with Yap inhibition shows promise in reducing liver fibrosis.