Findings reveal that enhancing metallothionein may prevent liver fibrosis by regulating zinc and iron levels.
These findings reveal MT as a key hepatocyte integrator of trace-metal homeostasis and Yap signalling and suggest that therapeutic strategies enhancing MT activity or combining Zn supplementation with Yap inhibition may offer new avenues to prevent or reverse chronic liver fibrosis.
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Feng et al. (2026) studied this question.
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