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March 29, 2026Journal of pharmacopuncture0 citationsOpen Access

Datura metel and Alcohol Cocktail Potentiates Hepatic Encephalopathy by Exacerbating Impairment via the Hepato-Prefrontal Cortical Axis

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EJEphraim Samuel JenAAAdeshina Oloruntoba AdekeyeMAMary Oluwatobiloba Adedigba

Key Points

  • The research aims to investigate how Datura metel and alcohol cocktails affect hepatic encephalopathy through their impact on the hepatic-prefrontal cortical axis.
  • Analyzed the effects of Datura metel and alcohol on liver function and cognitive impairment.
  • Examined the interactions between these substances and their neurotoxic effects.
  • Utilized behavioral assessments and biochemical evaluations to measure hepatic encephalopathy symptoms.
  • Alcohol and Datura metel significantly worsen cognitive impairment associated with hepatic encephalopathy.
  • Neurotoxicity was observed, particularly affecting the prefrontal cortex functionality.
  • Findings suggest a detrimental combined effect on brain function and liver health.

Abstract

Ephraim Samuel Jen, Adeshina Oloruntoba Adekeye , Mary Oluwatobiloba Adedigba, Edem Ekpeyong Edem, Musa Samaila Chiroma, Martha Orendu Oche Attah. J Pharmacopuncture 2026;29:48-60. https://doi.org/10.3831/KPI.2026.29.1.48

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Cite This Study

Jen et al. (2026) studied this question.

synapsesocial.com/papers/69c8c28cde0f0f753b39cf05https://doi.org/10.3831/kpi.2026.29.1.48
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