Chronic traumatic encephalopathy is a progressive neurodegenerative pathology characterized by tau protein accumulation and characteristic clinical symptoms that may be mediated by neurotransmitter disorders. The aim of the study. To evaluate the relationship between the concentration of neurotransmitters and tau protein in the cerebral cortex and hippocampus of rats with chronic traumatic encephalopathy. Pathology was modeled in Wistar rats. The levels of dopamine, glutamate, serotonin, GABA, glycine, acetylcholine, and tau protein were assessed in the hippocampus and cerebral cortex. It was found that in rats with chronic traumatic encephalopathy, the content of tau protein in the cerebral cortex and hippocampus increased by 27.5 times (p 0.05) and 14.1 times (p 0.05). There was also an increase in the levels of dopamine and glutamate, while the concentrations of serotonin, GABA, glycine and acetylcholine, on the contrary, decreased both in the hippocampus and in the cerebral cortex. Regression analysis revealed that the highest correlation is between the concentration of tau protein and glutamate (r = 0.9420 for the cerebral cortex and r = 0.9664 for the hippocampus).
Pozdnyakov et al. (2025) studied this question.