What is already known about this topic? Dengue virus (DENV) and Zika virus (ZIKV), primarily transmitted by Aedes aegypti and Aedes albopictus, belong to the Flaviviridae family. Their clinical presentations overlap considerably, including acute fever, nausea, rash, joint pain, and myalgia, making differential diagnosis challenging. What is added by this report? Because DENV and ZIKV share a common mosquito vector, their co-circulation increases the likelihood of dengue–Zika coinfection in both human and mosquito populations. This study documents the first laboratory-confirmed case of dengue/Zika coinfection in China. The patient presented with a fever on the day of entry. What are the implications for public health practice? This study provides a comprehensive epidemiological and phylogenetic analysis of a dengue/Zika coinfection case imported from Malaysia. Climate change and frequent cross-border travel are heightening the risk of imported mosquito-borne infectious diseases in China. International port cities must therefore strengthen surveillance and diagnostic testing for imported mosquito-borne diseases. For suspected febrile cases, clinicians should consider arbovirus coinfection based on travel history to prevent serious public health risks arising from missed diagnoses.
Liwen et al. (Thu,) studied this question.
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