Cover feature demonstrates reversible control using photoswitchable molecules in biological systems, suggesting new applications.
The Cover Feature shows trains travelling on a track: the engine (HaloTag) and wagon (eDHFR) are linked by a photoswitchable molecular coupler based on an azobenzene photoswitch. Blue light uncouples them, while green light restores binding. The infinity-shaped track symbolizes reversible control. More information can be found in the Concept by Y.-W. Wu and co-workers (DOI: 10.1002/cptc.202500267). Cover illustration by Ida Åberg.
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Herzog et al. (2026) studied this question.
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